Solubility measurement of poorly soluble drugs in fasted state simulated intestinal fluid
نویسندگان
چکیده
Adequatedrug solubility in the gastrointestinal tract is essential for systemic therapyof orally administered medications. To carry out research on ofpoorly soluble drugs vitro, simulated intestinal fluid (SIF) usedin place of human (HIF). However, typical SIF reflects averagecompositions HIF rather than full range compositions previouslyreported. This study examines a new suite media (based variabilityobserved HIF) to explore four poorly drugs(Naproxen, Indomethacin, Phenytoin and Tadalafil) fasted state.
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ژورنال
عنوان ژورنال: British journal of pharmacy
سال: 2022
ISSN: ['2058-8356']
DOI: https://doi.org/10.5920/bjpharm.1075